黄艳, 张春来, 稂文旺, 陈明生, 刘元, 刘布鸣. 毛萼清风藤中一个新的氧化阿朴菲碱类化合物J. 药学学报, 2018,53(5): 778-781. doi: 10.16438/j.0513-4870.2018-0122
引用本文: 黄艳, 张春来, 稂文旺, 陈明生, 刘元, 刘布鸣. 毛萼清风藤中一个新的氧化阿朴菲碱类化合物J. 药学学报, 2018,53(5): 778-781. doi: 10.16438/j.0513-4870.2018-0122
HUANG Yan, ZHANG Chun-lai, LANG Wen-wang, CHEN Ming-sheng, LIU Yuan, LIU Bu-ming. A new oxoaporphine from Sabia limoniacea var. ardisioidesJ. Acta Pharmaceutica Sinica, 2018,53(5): 778-781. doi: 10.16438/j.0513-4870.2018-0122
Citation: HUANG Yan, ZHANG Chun-lai, LANG Wen-wang, CHEN Ming-sheng, LIU Yuan, LIU Bu-ming. A new oxoaporphine from Sabia limoniacea var. ardisioidesJ. Acta Pharmaceutica Sinica, 2018,53(5): 778-781. doi: 10.16438/j.0513-4870.2018-0122

毛萼清风藤中一个新的氧化阿朴菲碱类化合物

A new oxoaporphine from Sabia limoniacea var. ardisioides

  • 摘要: 采用硅胶柱色谱、Sephadex LH-20、制备液相等多种色谱技术,对毛萼清风藤的95%乙醇提取物进行分离纯化。从中分离得到了8个化合物,根据化合物的光谱数据和理化性质鉴定为5-甲氧基-1,2-亚甲二氧基氧化阿朴菲碱(1)、5-氧阿朴菲碱(2)、N-p-阿魏酰酪胺(3)、N-反式香豆酰酪胺(4)、槲皮素(5)、芦丁(6)、mutabiloside(7)和原儿茶酸(8)。其中,化合物1为新化合物,化合物2~8均为首次从毛萼清风藤中分离得到。

     

    Abstract: The chemical constituents of Sabia limoniacea var. ardisioides were investigated using chroma­tographic methods, such as silica gel, Sephadex LH-20 and preparative HPLC. Eight compounds were isolated and their structures were elucidated by spectral data and physicochemical properties, which were identified as 5-methoxy-1,2-methylenedioxyl oxoaporphine (1), fuseine (2), N-p-feruloyltyramine (3), N-trans-coumaroyl tyramin (4), quercetin (5), rutin (6), mutabiloside (7), and protocatechuic acid (8). Among those, compound 1 is a new compound, compounds 28 were isolated from this plant for the first time.

     

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