吲哚胺2,3-双加氧酶1在肿瘤免疫治疗中的研究进展

Research progress of indoleamine 2,3-dioxygenase 1 in tumor immunotherapy

摘要: 吲哚胺2，3-双加氧酶1（indoleamine 2，3-dioxygenase 1，IDO1）是与肿瘤免疫机制密切相关的免疫检查点之一。众多研究表明，IDO1在乳腺癌、结直肠癌和肝癌等肿瘤组织中异常表达，通过多种途径参与肿瘤免疫逃逸机制。因此，本文旨在阐述IDO1的生物学功能及其在肿瘤逃逸中的重要作用，并介绍目前在临床研究阶段的IDO1抑制剂进展情况。

Abstract: IDO1 (indoleamine 2,3-dioxygenase 1) is one of the most significant checkpoint in tumor immunology. Numerous studies indicates that IDO1 is abnormally expressed in breast cancer, colorectal cancer, liver cancer and other tumor tissues, participating in tumor immune escape through multiple pathways. This review is prepared to elucidate the biological function of IDO1, highlight its pivotal role in tumor evasion, and summarize IDO1 inhibitors in the clinical trials.