马洁, 吉腾飞, 田晋, 王彦改, 杨建波, 苏亚伦, 王爱国. 贯叶金丝桃中一个新的2,3-二氧代黄酮J. 药学学报, 2019,54(12): 2286-2288. doi: 10.16438/j.0513-4870.2019-0618
引用本文: 马洁, 吉腾飞, 田晋, 王彦改, 杨建波, 苏亚伦, 王爱国. 贯叶金丝桃中一个新的2,3-二氧代黄酮J. 药学学报, 2019,54(12): 2286-2288. doi: 10.16438/j.0513-4870.2019-0618
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MA Jie, JI Teng-fei, TIAN Jin, WANG Yan-gai, YANG Jian-bo, SU Ya-lun, WANG Ai-guo. A new 2,3-dioxoflavonoid from the aerial part of Hypericum perforatumJ. Acta Pharmaceutica Sinica, 2019,54(12): 2286-2288. doi: 10.16438/j.0513-4870.2019-0618
Citation: MA Jie, JI Teng-fei, TIAN Jin, WANG Yan-gai, YANG Jian-bo, SU Ya-lun, WANG Ai-guo. A new 2,3-dioxoflavonoid from the aerial part of Hypericum perforatumJ. Acta Pharmaceutica Sinica, 2019,54(12): 2286-2288. doi: 10.16438/j.0513-4870.2019-0618
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贯叶金丝桃中一个新的2,3-二氧代黄酮

A new 2,3-dioxoflavonoid from the aerial part of Hypericum perforatum

    摘要
  • 摘要: 利用硅胶柱色谱、Sephedax LH-20、制备高效液相色谱等分离、纯化方法，从贯叶金丝桃（Hypericum perforatum L.）中分离得到一个新的黄酮类化合物，其结构经UV、IR、MS、HR-ESI-MS及核磁共振等波谱技术鉴定为：Rel-（2S，3R）-2-（3，4-dihydroxyphenyl）-3，5，7-trihydroxy-2-methoxy-3-（2-oxopropyl）chroman-4-one（1）。化合物1是一个含有一个丙酮基的2，3-二氧代黄酮类化合物，在自然界中较为罕见。此外，还对该化合物的可能生源途径进行了推测。

     

    Abstract: Phytochemical study of the aerial parts of Hypericum perforatum L. resulted in the isolation of an undescribed compound, which was identified as Rel-(2S,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2-methoxy-3-(2-oxopropyl)chroman-4-one (1) by spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR spectra. Compound 1 is a new 2,3-dioxo-flavone with an acetonyl moiety, rarely found in nature. In addition, a plausible biogenetic pathway of 1 was proposed in this article.

     

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