鹧鸪花果实trichilin-type柠檬苦素化学成分研究

Trichilin-type limonoids isolated from the fruits of Trichilia connaroides

摘要: 通过常压硅胶、凝胶、反相柱色谱和高压反相柱色谱等色谱技术对楝科植物鹧鸪花果实的化学成分进行研究，从鹧鸪花（Trichilia connaroides）果实乙醇提取物中分离获得4个trichilin-type柠檬苦素，包括2个新化合物和2个已知化合物3α-deacetylamoorastatin（3）和mesendanins K（4）。通过综合运用HR-ESI-MS、¹H NMR、¹³C NMR、HSQC、HMBC和ROESY等多种光谱分析方法确定了新化合物1、2的平面结构和相对构型。通过对分离获得的化合物进行肿瘤细胞毒活性研究，结果表明新化合物1、2和已知化合物4对宫颈癌细胞（HeLa）具有微弱的细胞毒活性。

Abstract: Two new trichilin-type limonoids were isolated from the fruits of Trichilia connaroides along with two known limonoids, 3α-deacetylamoorastatin (3) and mesendanins K (4). Their planar structure and relative configuration were elucidated by comprehensive analyses of HR-ESI-MS, ¹H NMR, ¹³C NMR, HSQC, HMBC and ROESY data. An antitumor activity assay showed that compounds 1, 2 and known compound 4 had weak cytotoxicity against a human cervical cancer cell line (HeLa).