药用植物活性成分生物合成中P450的研究进展

Research progress of P450 in the biosynthesis of bioactive compound of medicinal plants

摘要: 药用活性成分多来源于药用植物次生代谢产物，是其发挥药效的物质基础。细胞色素P450s（cytochrome P450s，P450s）是一类分布广泛、由超基因家族编码的含血红色素的单加氧酶，在植物的代谢网络中发挥重要作用。本文以熟知的几类药用植物活性成分为对象，对其生物合成途径中P450相关功能进行介绍，通过对P450在萜类、生物碱、黄酮以及苯丙烷类等常见药用植物活性成分生物合成中的功能进行综述，为药用植物次生代谢产物的生物合成及调控研究提供参考。

Abstract: Most of the active ingredients of herbs are secondary metabolites of plants. Cytochrome P450s (P450s) are hemoglobin-containing monooxygenases encoded by a super-gene family, which play important roles in the metabolic network of plants. This review focuses on the role of P450s on biosynthesis of secondary metabolites such as terpenoids, alkaloids, flavonoids and phenylpropanoids. This will provide references for biosynthesis and regulation of secondary metabolites in medicinal plants.