冠状病毒抑制剂研究的药物化学策略

Medicinal chemistry strategies in seeking coronavirus inhibitors

摘要: 冠状病毒感染所引起的疫情对人类健康造成严重威胁，但目前尚无特异性治疗药物或疫苗。本文从药物化学的视角，精选抗SARS-CoV、MERS-CoV等冠状病毒药物的研究案例，总结了药物发现策略，并分析了新近暴发的SARS-CoV-2感染疫情的药物研究新动向，提出了未来研究的新思路。

Abstract: The epidemic caused by coronavirus poses a serious threat to human health, but there is no specific drug or vaccine for the treatment of this kind of virus infection. Herein, this article selects typical case studies in recent years and reviews the medicinal chemistry strategies of anti-SARS-CoV, MERS-CoV and other coronavirus drugs from the perspective of medicinal chemistry, and tries to provide some clues to current drug research againstSARS-CoV-2.