张晓娟, 王彦志, 李曼倩, 宋志敏, 郭燕, 胡雪雨, 冯卫生. 干姜中五个新的姜辣素类化合物J. 药学学报, 2020,55(10): 2421-2427. doi: 10.16438/j.0513-4870.2020-0538
引用本文: 张晓娟, 王彦志, 李曼倩, 宋志敏, 郭燕, 胡雪雨, 冯卫生. 干姜中五个新的姜辣素类化合物J. 药学学报, 2020,55(10): 2421-2427. doi: 10.16438/j.0513-4870.2020-0538
ZHANG Xiao-juan, WANG Yan-zhi, LI Man-qian, SONG Zhi-min, GUO Yan, HU Xue-yu, FENG Wei-sheng. Five new gingerol compounds from Zingiberis Rhizoma J. Acta Pharmaceutica Sinica, 2020,55(10): 2421-2427. doi: 10.16438/j.0513-4870.2020-0538
Citation: ZHANG Xiao-juan, WANG Yan-zhi, LI Man-qian, SONG Zhi-min, GUO Yan, HU Xue-yu, FENG Wei-sheng. Five new gingerol compounds from Zingiberis Rhizoma J. Acta Pharmaceutica Sinica, 2020,55(10): 2421-2427. doi: 10.16438/j.0513-4870.2020-0538

干姜中五个新的姜辣素类化合物

Five new gingerol compounds from Zingiberis Rhizoma

  • 摘要: 运用Diaion HP-20、Sephadex LH-20、硅胶、半制备高效液相等多种色谱分离技术分离纯化研究干姜中化学成分,利用理化性质及MS和NMR波谱学技术鉴定了5个姜辣素类化合物:4-(2-丁基-6-甲基-4H-吡喃-4-基)-2-甲氧基苯酚(1)、4-(2-己基-6-甲基-4H-吡喃-4-基)-2-甲氧基苯酚(2)、1-(4-羟基-3-甲氧基苯基)十三烷-3,5-二醇(3)、10-gingerdiol(4)和1-1-(4-羟基-3-甲氧基苯基)-3-氧代-5-基吡咯烷-2-酮(5a5b),化合物1~35a5b均为新化合物。

     

    Abstract: We separated and purified five chemical constituents of dried ginger by Diaion HP-20, Sephadex LH-20, silica gel and semi-preparative high performance liquid chromatography. Five gingerols were identified by physicochemical properties and MS and NMR spectroscopy techniques:4-(2-butyl-6-methyl-4H-pyran-4-yl)-2-methoxyphenol (1), 4-(2-hexyl-6-methyl-4H-pyran-4-yl)-2-methoxyphenol (2), 1-(4-hydroxy-3-methoxyphenyl)tridecane-3,5-diol (3),10-gingerdiol (4) and 1-1-(4-hydroxy-3-methoxy phenyl)-3-oxodecan-5-ylpyrrolidin-2-one (5a, 5b). Compounds 1-3, 5a, 5b are new compounds.

     

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