Abstract: The interaction between platelets and tumor cells can not only promote the metastasis of malignant tumors, but also affect the formation of malignant tumor-related thrombus. When tumor cells enter the blood, they will immediately activate platelets to make them adhere to the surface of tumor cells, protecting tumor cells from blood flow shear force and immune system attack, thereby promoting tumor metastasis. At the same time, the massive adhesion of platelets may also lead to the formation of thrombus. In this article, we use the methods of ingenuity pathway analysis and literature integration to explore the mechanism of platelet-tumor cell interaction and potential drugs for the treatment of malignant tumor metastasis based on the platelet-tumor cell interaction. It provides a certain theoretical basis and clinical reference for the future development of new drugs targeting platelet-tumor cell interaction based on its mechanism of action.