藏药甘青乌头中1个新的双二萜生物碱

A novel dimeric diterpenoid alkaloid from the Tibetan medicinal plant Aconitum tanguticum (Maxim.) Stapf

摘要: 从甘青乌头全草中分得两个双二萜生物碱，经1D，2D-NMR及HR-MS数据解析确定了它们的结构，其中1个为新化合物，命名为tanguticurine A（1），另1个为已知化合物anthoroidine B（2），二者均为首次从甘青乌头中分离得到。抗病毒实验结果显示化合物1对HCV和EV71均有较好的抑制作用，半数有效浓度（EC₅₀）分别为15.5和9.7 μmol·L^-1，并显示较低的细胞毒性。因此，化合物1是一个较好的抗病毒先导化合物，值得深入研究。

Abstract: Two dimeric diterpenoid alkaloids were isolated from the whole plant of Aconitum tanguticum (Maxim.) Stapf and their structures were elucidated by extensive analysis of 1D, 2D-NMR and HR-MS data. One is a new compound and named tanguticurine A (1), and the other is the known compound anthoroidine B (2); both were isolated from this plant for the first time. The antiviral activity of compounds 1 and 2 against HCV and EV71 were also evaluated. It was found that compound 1 had a good inhibitory effect on HCV and EV71 with EC₅₀ values of 15.5 and 9.7 μmol·L^-1, respectively, and showed low cytotoxicity. Therefore, compound 1 is a good antiviral lead compound and deserves further study.