熊志伟#, 宁汝曦#, 赵樱霞, 胡晓欣, 杨冰, 廉源沛, 封亮*, 贾晓斌*. 中药制剂前物料的性质体系及其表征技术研究J. 药学学报, 2021,56(8): 2048-2058. doi: 10.16438/j.0513-4870.2021-0801
引用本文: 熊志伟#, 宁汝曦#, 赵樱霞, 胡晓欣, 杨冰, 廉源沛, 封亮*, 贾晓斌*. 中药制剂前物料的性质体系及其表征技术研究J. 药学学报, 2021,56(8): 2048-2058. doi: 10.16438/j.0513-4870.2021-0801
XIONG Zhi-wei#, NING Ru-xi#, ZHAO Ying-xia, HU Xiao-xin, YANG Bing, LIAN Yuan-pei, FENG Liang*, JIA Xiao-bin*. The overview of the property system and characterization techniques of Chinese medicine materials before the pharmaceuticalJ. Acta Pharmaceutica Sinica, 2021,56(8): 2048-2058. doi: 10.16438/j.0513-4870.2021-0801
Citation: XIONG Zhi-wei#, NING Ru-xi#, ZHAO Ying-xia, HU Xiao-xin, YANG Bing, LIAN Yuan-pei, FENG Liang*, JIA Xiao-bin*. The overview of the property system and characterization techniques of Chinese medicine materials before the pharmaceuticalJ. Acta Pharmaceutica Sinica, 2021,56(8): 2048-2058. doi: 10.16438/j.0513-4870.2021-0801

中药制剂前物料的性质体系及其表征技术研究

The overview of the property system and characterization techniques of Chinese medicine materials before the pharmaceutical

  • 摘要: 中药制剂现代化进程中面临诸多挑战,中药粉末、中药提取物和中药组分作为中药制剂前最具有代表性的3类物料,其性质是指导中药制剂剂型设计的核心基础。本团队在长期研究中药制剂物料性质的基础上,根据中药制剂物料在一定条件所处的状态及物质之间相互作用特点,构建了中药制剂物料的性质体系,由物质构成、空间构造、体性质、面性质及理化性质5大类18小类构成,并进一步建立了相应的指标体系,包含61项指标及表征技术,为中药制剂的现代化奠定基础。

     

    Abstract: At present, the modernization of Chinese medicine preparations (CMPs) is still a challenging task. The 3 typical Chinese medicine materials (CMMs) used for preparing CMPs are the powders, extracts, and components of Chinese medicine and their properties of CMMs are important for designing CMPs. Basing on our long term research, we have established a property system for CMMs according to the state of CMMs under an exactly condition and according to the interaction characteristics between substances. The property system could be divided into 5 categories:material composition, spatial structure, body property, surface property, physicochemical properties, and they could also be divided into 18 subcategories. Furthermore, we also established the corresponding index and characterization system, where the 61 indexes and characterization techniques were systematically summarized. At last, we hope that the article will promote the modernization of CMPs.

     

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