王珏, 胡丽, 武美芹, 杨锐, 孙会敏, 涂家生. NMR技术测定PVPP交联度及其粉体可压缩性研究J. 药学学报, 2022,57(2): 474-479. doi: 10.16438/j.0513-4870.2021-0937
引用本文: 王珏, 胡丽, 武美芹, 杨锐, 孙会敏, 涂家生. NMR技术测定PVPP交联度及其粉体可压缩性研究J. 药学学报, 2022,57(2): 474-479. doi: 10.16438/j.0513-4870.2021-0937
WANG Jue, HU Li, WU Mei-qin, YANG Rui, SUN Hui-min, TU Jia-sheng. Study on the cross-linking degree of PVPP by NMR technology and its powder compressibilityJ. Acta Pharmaceutica Sinica, 2022,57(2): 474-479. doi: 10.16438/j.0513-4870.2021-0937
Citation: WANG Jue, HU Li, WU Mei-qin, YANG Rui, SUN Hui-min, TU Jia-sheng. Study on the cross-linking degree of PVPP by NMR technology and its powder compressibilityJ. Acta Pharmaceutica Sinica, 2022,57(2): 474-479. doi: 10.16438/j.0513-4870.2021-0937

NMR技术测定PVPP交联度及其粉体可压缩性研究

Study on the cross-linking degree of PVPP by NMR technology and its powder compressibility

  • 摘要: 本文采用低场核磁共振技术Carr-Purcell-Meiboom-Gill(CPMG)回波法测定了不同厂家交联聚维酮(crospovidone,PVPP)的交联度和交联密度,在交联聚维酮7个物理属性基础上建立了20个二级质量指标的物理指纹图谱,通过指纹图谱计算得到3个可压性评价指标:参数指数(index of parameter,IP)、参数轮廓指数(index of parametric profile,IPP)、良好可压性指数(index of good compression,IGC)。相关性分析发现交联聚维酮的交联度与可压性指标IP的相关性系数为0.816,呈现强相关性,表明交联聚维酮的交联度是影响其可压性的重要质量指标之一。

     

    Abstract: In this paper, the low-field nuclear magnetic resonance technology CPMG (Carr-Purcell-Meiboom-Gill) echo method was used to determine the cross-linking degree and cross-linking density of crospovidone (PVPP) from different manufacturers. Based on the seven physical properties of PVPP, a fingerprint spectrum (radar chart) of twenty secondary quality indicators were obtained, and three compressibility evaluation indicators, index of the parameter (IP), index of parametric profile (IPP), index of good compression (IGC) were calculated by the fingerprint spectrum. It was found that the cross-linking degree and compressibility index IP of PVPP showed a strong correlation (r=0.816) by the correlation analysis, indicating that the cross-linking degree is one of the key quality attributes for evaluating the compressibility of PVPP.

     

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