蜘蛛香中的倍半萜和环烯醚萜类成分及其抗炎和抗流感病毒活性

Sesquiterpenoids and iridoids from Valeriana jatamansi with anti-inflammatory and anti-influenza virus properties

摘要: 采用多种色谱技术从蜘蛛香根和根茎中分离得到3个倍半萜和9个环烯醚萜，并依据理化性质、NMR和MS数据鉴定了化合物的结构。其中，蜘蛛香酯G（1）是新的广藿香醇型倍半萜，化合物3为首次从缬草属植物中分离得到。化合物3和10可显著抑制脂多糖（LPS）诱导的小鼠巨噬细胞RAW 264.7中NO的释放，IC₅₀值分别为19.00和3.66 μmol·L^-1。化合物4、6和12具有一定的抗流感病毒活性，IC₅₀值分别为51.75、51.40和102.08 μmol·L^-1。

Abstract: Three sesquiterpenoids and nine iridoids were isolated from the roots and rhizomes of Valeriana jatamansi by various chromatographic methods. Their structures were identified by physicochemical properties, NMR and MS data. Among them, valeriananoid G (1) was a new patchoulol-type sesquiterpenoid, and compound 3 was isolated from the genus Valeriana for the first time. Compounds 3 and 10 exhibited significant inhibitory effects on nitric oxide production induced by lipopolysaccharide in RAW 264.7 macrophages, with IC₅₀ values of 19.00 and 3.66 μmol·L^-1, respectively. In addition, compounds 4, 6 and 12 showed anti-influenza virus activity with IC₅₀ values of 51.75, 51.40 and 102.08 μmol·L^-1, respectively.