苏晓渝, 李彪, 陈水燕, 王新敏, 郑琴, 杨明, 岳鹏飞. 多孔材料吸附技术改善中药挥发油稳定性的研究与应用J. 药学学报, 2022, 57(11): 3301-3309. DOI: 10.16438/j.0513-4870.2022-0499
引用本文: 苏晓渝, 李彪, 陈水燕, 王新敏, 郑琴, 杨明, 岳鹏飞. 多孔材料吸附技术改善中药挥发油稳定性的研究与应用J. 药学学报, 2022, 57(11): 3301-3309. DOI: 10.16438/j.0513-4870.2022-0499
SU Xiao-yu, LI Biao, CHEN Shui-yan, WANG Xin-min, ZHENG Qin, YANG Ming, YUE Peng-fei. Research and application of porous materials adsorption technology to improve the stability of volatile oil of traditional Chinese medicineJ. Acta Pharmaceutica Sinica, 2022, 57(11): 3301-3309. DOI: 10.16438/j.0513-4870.2022-0499
Citation: SU Xiao-yu, LI Biao, CHEN Shui-yan, WANG Xin-min, ZHENG Qin, YANG Ming, YUE Peng-fei. Research and application of porous materials adsorption technology to improve the stability of volatile oil of traditional Chinese medicineJ. Acta Pharmaceutica Sinica, 2022, 57(11): 3301-3309. DOI: 10.16438/j.0513-4870.2022-0499

多孔材料吸附技术改善中药挥发油稳定性的研究与应用

Research and application of porous materials adsorption technology to improve the stability of volatile oil of traditional Chinese medicine

  • 摘要: 中药挥发油作为芳香类中药中的主要化学成分, 具有显著的抗菌、抗炎、抗氧化等药理作用。然而, 中药挥发油易挥发、易氧化变质等不稳定性问题严重限制了其制剂应用。多孔材料作为一种网格结构材料, 具有高比表面积、孔体积大、孔径可调、吸附能力强及表面化学性能可控等特点, 已被广泛应用于吸附分离、生物医学、工业催化、废水处理等领域。近年来利用多孔材料吸附挥发油, 为改善中药挥发油的稳定性提供了新的策略方法, 同时可实现中药挥发油的固化稳定与制剂应用。本文重点对介孔二氧化硅、介孔碳、介孔纳米羟基磷灰石、多孔金属有机框架、多孔淀粉等多孔材料的发展、特点及其在改善中药挥发油稳定性能的应用研究进行综述, 并探讨了影响多孔介质对中药挥发油吸附稳定性能的研究策略, 以期为中药挥发油的稳定化控制与应用提供参考与借鉴。

     

    Abstract: As the main chemical component of aromatic traditional Chinese medicine (TCM), the volatile oil of TCM has significant pharmacological effects, such as antibacterial, anti-inflammatory, antioxidant and so on. However, TCM volatile oil is easy to volatilize and oxidize, which seriously limits its application. As a kind of grid structure material, porous material has the characteristics of high specific surface area, large pore volume, adjustable pore size, strong adsorption capacity and controllable surface chemical properties. It has been widely used in adsorption separation, biomedicine, industrial catalysis, wastewater treatment and other fields. In recent years, the use of porous materials to adsorb volatile oil has provided a new strategy and method for improving the stability of TCM volatile oils. At the same time, it can realize the solidification and stability of TCM volatile oils and the application of preparations. In this review, the development and characteristics of porous materials such as mesoporous silica, mesoporous carbon, mesoporous nano hydroxyapatite, porous metal organic framework, porous starch and their application in improving the stability of TCM volatile oils are summarized, and the research strategies affecting the adsorption stability of porous materials for TCM volatile oils are discussed, in order to provide reference for the stabilization control and application of TCM volatile oils.

     

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