左甜甜, 刘佳琳, 李依玲, 金红宇, 费毅琴, 聂晶, 魏晟, 马双成. 中草药重金属及有害元素健康风险评估新视角——概率风险评估, 以车前草为例J. 药学学报, 2022, 57(11): 3365-3370. DOI: 10.16438/j.0513-4870.2022-0586
引用本文: 左甜甜, 刘佳琳, 李依玲, 金红宇, 费毅琴, 聂晶, 魏晟, 马双成. 中草药重金属及有害元素健康风险评估新视角——概率风险评估, 以车前草为例J. 药学学报, 2022, 57(11): 3365-3370. DOI: 10.16438/j.0513-4870.2022-0586
shu
ZUO Tian-tian, LIU Jia-lin, LI Yi-ling, JIN Hong-yu, FEI Yi-qin, NIE Jing, WEI Sheng, MA Shuang-cheng. A novel perspective of health risk assessment of heavy metals in Chinese herbal medicine—Probabilistic risk assessment, taking Plantago asiatica L. as an exampleJ. Acta Pharmaceutica Sinica, 2022, 57(11): 3365-3370. DOI: 10.16438/j.0513-4870.2022-0586
Citation: ZUO Tian-tian, LIU Jia-lin, LI Yi-ling, JIN Hong-yu, FEI Yi-qin, NIE Jing, WEI Sheng, MA Shuang-cheng. A novel perspective of health risk assessment of heavy metals in Chinese herbal medicine—Probabilistic risk assessment, taking Plantago asiatica L. as an exampleJ. Acta Pharmaceutica Sinica, 2022, 57(11): 3365-3370. DOI: 10.16438/j.0513-4870.2022-0586
shu

中草药重金属及有害元素健康风险评估新视角——概率风险评估, 以车前草为例

A novel perspective of health risk assessment of heavy metals in Chinese herbal medicine—Probabilistic risk assessment, taking Plantago asiatica L. as an example

    摘要
  • 摘要: 建立符合中药使用特点的重金属及有害元素概率风险评估方法, 以期为中药的安全使用提供指导, 采用电感耦合等离子体质谱法(ICP-MS)对21批车前草中铅(Pb)、镉(Cd)、砷(As)、汞(Hg)和铜(Cu)的残留量进行测定; 结合中药消费模式调查, 基于蒙特卡洛模拟技术分别采用风险熵(HQ)和致癌风险(CR)对车前草中重金属及有害元素导致的非致癌性和致癌性健康风险进行概率评估; 通过敏感性分析筛选出风险贡献最为显著的因素。结果车前草中铅、镉、砷、汞、铜的均值分别为9.01、0.28、3.83、0.01和12.82mg·kg-1。男性HQAS的P95分位值、P99分位值和最大值分别为1.41、2.83和10.97;女性HQAS的P95分位值、P99分位值和最大值分别为1.27、2.63、9.80。男性HI的P95分位值、P99分位值和最大值分别为1.44、2.85、11.0;女性HI的P95分位值、P99分位值和最大值分别为1.29、2.66、10.0。无论男性还是女性, CRAs和总致癌风险(TCR)的P99分位值、最大值均大于10-4。风险评估结果说明砷暴露引起的高端暴露人群非致癌性和致癌性健康风险均需要被关注。敏感性分析结果显示, 中药服用频率和车前草中砷的浓度是最主要的风险影响因素。本研究基于蒙特卡洛模拟技术, 并考虑中药服用特点, 首次提出中草药重金属及有害元素健康风险概率风险评估范例, 为中药重金属及有害元素健康风险评估提供新视角。

     

    Abstract: In order to establish the probabilistic risk assessment method for heavy metals and harmful elements in line with the characteristics of traditional Chinese medicine (TCM) and provide guidance for the safe use of TCM, the contents of lead (Pb), cadmium (Cd), arsenic (as), mercury (Hg) and copper (Cu) in 21 batches of Plantago asiatica L. were determined by inductively coupled plasma mass spectrometry (ICP-MS). By the comprehensive use of investigation of TCM consumption pattern and Monte Carlo simulation technology, the non-carcinogenic and carcinogenic health risks of heavy metals and harmful elements in TCM were assessed by hazard quotient (HQ) and cancer risk (CR), respectively. The greatest risk contributors were screened through sensitivity analysis. The results revealed that the mean contents of Pb, Cd, As, Hg and Cu in Plantago asiatica L. were 9.01, 0.28, 3.83, 0.01 and 12.82 mg·kg-1, respectively. The P95, P99 and maximum values of HQ for males were 1.41, 2.83 and 10.97 mg·kg-1, respectively. The P95, P99 and maximum values of HQ for females were 1.27, 2.63 and 9.80 mg·kg-1, respectively. The P95, P99 and maximum values of HI for males were 1.44, 2.85 and 11.0 mg·kg-1, respectively. The P95, P99 and maximum values of HI for females were 1.29, 2.66 and 10.0 mg·kg-1, respectively. The P99 and maximum values for CRAs and total carcinogenic risk (TCR) were greater than 10-4 for both men and women. The risk assessment results indicated that the non-carcinogenic and carcinogenic health risks of high exposure population caused by arsenic exposure are needed to be concern. The results of sensitivity analysis showed that the exposure frequency of TCM and the arsenic concentrations in Plantago asiatica L. were the main risk contributors. Based on Monte Carlo simulation technology and considering the characteristics of TCM, this study puts forward the first example of probabilistic risk assessment of heavy metals and harmful elements in Chinese herbal medicine, which provides a novel perspective for health risk assessment of heavy metals in TCM.

     

    • HTML全文
    • 参考文献(27)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回