山蜡梅叶中1个新的愈创木烷型倍半萜

A new guaiane-sesquiterpenoid from the leaves of Chimonanthus nitens Oliv.

摘要: 运用硅胶柱色谱、ODS柱色谱、Sephadex LH-20柱色谱及半制备高效液相等多种色谱分离技术, 从山蜡梅叶中分离得到9个化合物, 通过质谱、核磁共振波谱以及单晶衍射数据, 分别鉴定为: chimnitensene B (1)、1α-hydroxyisodauc-4-en-15-al (2)、trans-4, 5-dihydroxycorocalane (3)、trefoliol B (4)、oplopanone (5)、oplodiol (6)、3-(3'-hydroxybutyl)-2, 4, 4-trimethylcyclohexa-2, 5-dienone (7)、9(S)-4-oxo-7, 8-dihydro-β-ionol (8) 和saniculamoid D (9)。其中, 化合物1为新的愈创木烷型倍半萜, 化合物2~9为首次从山蜡梅植物中分离得到。

Abstract: Nine compounds were isolated from the leaves of Chimonanthus nitens Oliv. by silica gel, ODS, Sephadex LH-20 column chromatography and semi-preparative HPLC. They were identified as chimnitensene B (1), 1α-hydroxyisodauc-4-en-15-al (2), trans-4, 5-dihydroxycorocalane (3), trefoliol B (4), oplopanone (5), oplodiol (6), 3-(3'-hydroxybutyl)-2, 4, 4-trimethylcyclohexa-2, 5-dienone (7), 9(S)-4-oxo-7, 8-dihydro-β-ionol (8), and saniculamoid D (9) respectively, by MS, NMR and single crystal diffraction. Among them, compound 1 is a new guaiane-sesquiterpenoid, and compounds 2-9 were isolated from this plant for the first time.