关玮伟, 黄旻, 张欢, 游龙泰, 冯利萍, 杨敏, 梅冬, 王晓玲. 两种口服溶剂介质临时调配后的稳定性考察及口感评价J. 药学学报, 2023, 58(11): 3198-3203. DOI: 10.16438/j.0513-4870.2023-0535
引用本文: 关玮伟, 黄旻, 张欢, 游龙泰, 冯利萍, 杨敏, 梅冬, 王晓玲. 两种口服溶剂介质临时调配后的稳定性考察及口感评价J. 药学学报, 2023, 58(11): 3198-3203. DOI: 10.16438/j.0513-4870.2023-0535
GUAN Wei-wei, HUANG Min, ZHANG Huan, YOU Long-tai, FENG Li-ping, YANG Min, MEI Dong, WANG Xiao-ling. Stability and taste evaluation of two kinds of oral solvent after extemporaneous compoundingJ. Acta Pharmaceutica Sinica, 2023, 58(11): 3198-3203. DOI: 10.16438/j.0513-4870.2023-0535
Citation: GUAN Wei-wei, HUANG Min, ZHANG Huan, YOU Long-tai, FENG Li-ping, YANG Min, MEI Dong, WANG Xiao-ling. Stability and taste evaluation of two kinds of oral solvent after extemporaneous compoundingJ. Acta Pharmaceutica Sinica, 2023, 58(11): 3198-3203. DOI: 10.16438/j.0513-4870.2023-0535

两种口服溶剂介质临时调配后的稳定性考察及口感评价

Stability and taste evaluation of two kinds of oral solvent after extemporaneous compounding

  • 摘要: 制备可用于临时调配的果味溶剂和混悬溶剂介质, 考察两种介质载药前后的稳定性, 并使用电子舌技术对临时调配后的混悬液进行口感评价。两种介质在影响因素试验、加速试验和长期试验条件下保持稳定。两种介质的外观性状均未发生改变。果味溶剂相对密度维持在1.053~1.075, pH稳定在4.2~4.5。混悬溶剂相对密度维持在0.999~1.022, pH稳定在4.0~4.5。将华法林钠片、螺内酯片等7种药品与这两种口服溶剂介质混合, 分别进行含量均匀性和稳定性检测, 结果显示加药后临时调配制剂能够均匀分散, 理化性质稳定。口感评价结果显示在卡托普利组和水合氯醛组中, 果味溶剂矫味效果最佳。在华法林钠组、利福平组、螺内酯组、维生素B1组和维生素B2组中均是复合溶剂矫味效果最好。

     

    Abstract: A flavoring agent and a suspension agent were prepared for extemporaneous compounding. The stability of the two agents before and after drug loading was investigated, and the taste of the suspension after extemporaneous compounding was evaluated by electronic tongue technology. The two agents remained stable under the conditions of influence factor test, accelerated test and long-term test. The appearance properties of the two agents did not change. The relative density of the flavoring agent was maintained at 1.053-1.075, and the pH was stable at 4.2-4.5. The relative density of the suspension agent was maintained at 0.999-1.022, and the pH was stable at 4.0-4.5. Seven kinds of drugs, including warfarin sodium tablets and spironolactone tablets, were mixed with these two oral solvents, and the content uniformity and stability were detected respectively. The results showed that the preparations could be evenly dispersed and the physical and chemical properties were stable. The results of taste evaluation showed that in captopril group and chloral hydrate group, the flavoring agent had the best effect on taste correction. In warfarin sodium group, rifampicin group, spironolactone group, vitamin B1 group and vitamin B2 group, the blending agents had the best effect on taste correction.

     

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