王亚玲, 陈琳, StephenChibuzor, 孟凡成, 陈敏, 王国伟. 木瓣树中3个新的倍半萜类化合物及其法尼醇X受体激活作用研究J. 药学学报, 2024, 59(5): 1341-1347. DOI: 10.16438/j.0513-4870.2023-1248
引用本文: 王亚玲, 陈琳, StephenChibuzor, 孟凡成, 陈敏, 王国伟. 木瓣树中3个新的倍半萜类化合物及其法尼醇X受体激活作用研究J. 药学学报, 2024, 59(5): 1341-1347. DOI: 10.16438/j.0513-4870.2023-1248
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WANG Ya-ling, CHEN Lin, Stephen Chibuzor, MENG Fan-cheng, CHEN Min, WANG Guo-wei. Three new sesquiterpenes from Xylopia vielana Pierre and their effects of farnesoid X receptor activationJ. Acta Pharmaceutica Sinica, 2024, 59(5): 1341-1347. DOI: 10.16438/j.0513-4870.2023-1248
Citation: WANG Ya-ling, CHEN Lin, Stephen Chibuzor, MENG Fan-cheng, CHEN Min, WANG Guo-wei. Three new sesquiterpenes from Xylopia vielana Pierre and their effects of farnesoid X receptor activationJ. Acta Pharmaceutica Sinica, 2024, 59(5): 1341-1347. DOI: 10.16438/j.0513-4870.2023-1248
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木瓣树中3个新的倍半萜类化合物及其法尼醇X受体激活作用研究

Three new sesquiterpenes from Xylopia vielana Pierre and their effects of farnesoid X receptor activation

    摘要
  • 摘要: 采用硅胶、ODS和半制备HPLC等多种色谱学技术从木瓣树枝叶中分离得到了11个化合物。化学结构经高分辨质谱、核磁共振谱、ECD等多种波谱分析方法, 鉴定为: vielana A (1)、vielana B (2)、vielana C (3)、10-oxo-isodauc-3-en-15-al (4)、1α-hydroxyisodauc-4-en-15-al (5)、mokko lactone (6)、11β,13-dihydrocostunolide (7)、eurylosesquiterpenol E (8)、epi-α-cadinol (9)、mustakone (10)、7-epi-amiteo (11)。化合物1~3为新化合物, 其余化合物均首次从木瓣树中分离得到。化合物1和2增加了法尼醇X受体(farnesoid X receptor, FXR) 下游靶基因BSEP启动子的转录活性, 表明其具有潜在的FXR激活作用。

     

    Abstract: Eleven compounds were isolated from the twigs and leaves of Xylopia vielana Pierre by various chromatographic techniques such as silica gel, ODS and the semi-preparative HPLC. Their chemical structures were identified by HR-ESI-MS, NMR, ECD and other spectroscopic methods as vielana A (1), vielana B (2), vielana C (3), 10-oxo-isodauc-3-en-15-al (4), 1α-hydroxyisodauc-4-en-15-al (5), mokko lactone (6), 11β,13-dihydrocostunolide (7), eurylosesquiterpenol E (8), epi-α-cadinol (9), mustakone (10), 7-epi-amiteo (11). Among them, compounds 1-3 were new compounds, and the rest compounds were isolated from this plant for the first time. Compounds 1 and 2 increased the transcriptional activity of the farnesoid X receptor (FXR) downstream target gene BSEP promoter, indicating that they have potential of FXR activation.

     

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