唐志强, 吴杰, 洪晓轩, 韩晓璐, 段姝伟, 张慧, 刘楠, 王增明, 郑爱萍. 3D打印口服固体制剂: 打印材料的研究应用J. 药学学报, 2025, 60(9): 2776-2787. DOI: 10.16438/j.0513-4870.2024-0145
引用本文: 唐志强, 吴杰, 洪晓轩, 韩晓璐, 段姝伟, 张慧, 刘楠, 王增明, 郑爱萍. 3D打印口服固体制剂: 打印材料的研究应用J. 药学学报, 2025, 60(9): 2776-2787. DOI: 10.16438/j.0513-4870.2024-0145
TANG Zhi-qiang, WU Jie, HONG Xiao-xuan, HAN Xiao-lu, DUAN Shu-wei, ZHANG Hui, LIU Nan, WANG Zeng-ming, ZHENG Ai-ping. 3D printing of oral solid dosage forms: research and applications of printing materialsJ. Acta Pharmaceutica Sinica, 2025, 60(9): 2776-2787. DOI: 10.16438/j.0513-4870.2024-0145
Citation: TANG Zhi-qiang, WU Jie, HONG Xiao-xuan, HAN Xiao-lu, DUAN Shu-wei, ZHANG Hui, LIU Nan, WANG Zeng-ming, ZHENG Ai-ping. 3D printing of oral solid dosage forms: research and applications of printing materialsJ. Acta Pharmaceutica Sinica, 2025, 60(9): 2776-2787. DOI: 10.16438/j.0513-4870.2024-0145

3D打印口服固体制剂: 打印材料的研究应用

3D printing of oral solid dosage forms: research and applications of printing materials

  • 摘要: 随着精准医学医疗理念的提出, 医药治疗正在从“一刀切”转向个性化。3D打印作为一种新兴制剂技术, 可极大提升制剂的复杂度与灵活性, 解决传统工艺的诸多问题, 实现个性化的药物治疗。近年来, 随着3D打印技术的快速发展, 已有多种3D打印技术用于口服固体制剂的开发。鉴于3D打印技术种类及特性的区别, 需要根据打印技术的应用特点选择合适的打印材料, 材料的选择对于口服固体制剂的个性化成型与精准释放均可产生重要影响。本文综述了适用于口服固体制剂3D打印的熔融沉积成型技术、半固体挤出技术、热熔挤出沉积技术, 以及黏结剂喷射技术的原理与特点, 并详细探讨了常用3D打印制剂技术对打印材料的选择与应用, 旨在为制备不同原理3D打印口服固体制剂的材料选择提供指导。

     

    Abstract: With the introduction of the concept of precision medicine, pharmaceutical treatment is shifting from 'one-size-fits-all' to personalization, and 3D printing, as an emerging formulation technology, can significantly enhance the complexity and flexibility of formulations, solve the many problems of the traditional process, and achieve personalized drug therapy. In recent years, with the rapid development of 3D printing technology, various 3D printing technologies have been used to develop oral solid dosage forms. Given the differences in the types and characteristics of 3D printing technologies, it is necessary to select appropriate printing materials according to the application characteristics of printing technology, and the choice of materials can significantly impact the personalized shaping and precise release of oral solid dosage forms. This paper lists the principles and characteristics of fused deposition molding technology, semi-solid extrusion technology, melt extrusion deposition technology, and binder jetting technology, which is suitable for the 3D printing of oral solid preparations. It explores the selection and application of printing materials for commonly used 3D printing technologies in detail to guide the choice of materials to prepare different principles of 3D printing of oral solid preparations.

     

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