付成效, 陈临溪. 从高尔基体自噬到高尔基体医学——以高尔基体为靶标的疾病防治新策略J. 药学学报, 2025, 60(2): 280-287. DOI: 10.16438/j.0513-4870.2024-0994
引用本文: 付成效, 陈临溪. 从高尔基体自噬到高尔基体医学——以高尔基体为靶标的疾病防治新策略J. 药学学报, 2025, 60(2): 280-287. DOI: 10.16438/j.0513-4870.2024-0994
FU Cheng-xiao, CHEN Lin-xi. From Golgiphagy to Golgimedicine — a new strategy for disease prevention and treatment targeting the Golgi apparatusJ. Acta Pharmaceutica Sinica, 2025, 60(2): 280-287. DOI: 10.16438/j.0513-4870.2024-0994
Citation: FU Cheng-xiao, CHEN Lin-xi. From Golgiphagy to Golgimedicine — a new strategy for disease prevention and treatment targeting the Golgi apparatusJ. Acta Pharmaceutica Sinica, 2025, 60(2): 280-287. DOI: 10.16438/j.0513-4870.2024-0994

从高尔基体自噬到高尔基体医学——以高尔基体为靶标的疾病防治新策略

From Golgiphagy to Golgimedicine — a new strategy for disease prevention and treatment targeting the Golgi apparatus

  • 摘要: 高尔基体的结构破坏和功能性障碍对生物体的健康有害, 导致各种疾病。去除受损的高尔基体对于维持细胞稳态至关重要, 高尔基体自噬逐渐引起大家的关注。本文对高尔基体自噬进行了总结, 简述了高尔基体自噬的特点和作用、高尔基体自噬受体、高尔基体自噬在疾病治疗中的作用, 并提出高尔基体医学(Golgimedicine) 这一新概念, 由此展望了高尔基体在疾病诊断、治疗和预后、遗传病和罕见病的作用。本文旨在从Golgimedicine角度探索高尔基体自噬、高尔基体结构和功能的科学内涵, 为药物靶标研究、新药开发以及人类健康发展提供理论参考。

     

    Abstract: Functional disorders of the Golgi apparatus are harmful to the health of organisms, leading to various diseases. Removing damaged Golgi apparatus is crucial for maintaining cellular homeostasis, therefore, autophagy of Golgi apparatus has gradually attracted attention. This article summarizes Golgi autophagy, briefly describes its structure and functions, Golgi autophagy receptors, and the role of Golgi autophagy in disease treatment. It also proposes the new concept of Golgimedicine, which looks forward to the role of Golgi in disease diagnosis, treatment, prognosis, genetic diseases, and rare diseases. This article aims to explore the scientific connotations of Golgi autophagy, Golgi structure and function from the perspective of Golgimedicine, providing theoretical references for drug target research, new drug development, and the healthy development of humanity.

     

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