聚乙二醇化重组人生长激素在大鼠体内的药代动力学研究

Pharmacokinetics of rhGH decorated by polyethylene glycol in rat in vivo

摘要:
用¹²⁵I标记示踪法研究大鼠皮下注射聚乙二醇化重组人生长激素（PEG-rhGH）药代动力学特征。大鼠sc PEG-rhGH后，测定血清PEG-rhGH浓度，用3P97程序拟和分析并计算药代动力学参数。大鼠sc PEG-rhGH 150、300或600 μg·kg^-¹后，药物消除符合一房室模型。经与相关文献比较可知，生长激素经PEG化修饰后能延长其在体内的作用时间，达到长效目的。

Abstract:
To study the pharmacokinetics of rhGH decorated by polyethylene glycol (PEG-rhGH) after sc administration in rat, serum PEG-rhGH concentrations were measured by ¹²⁵I labeled method after sc in rat, the pharmacokinetic model and parameters were fitted and calculated by the 3P97 program. After sc injection at doses of 150, 300, and 600 μg·kg^-¹ in rat, the serum PEG-rhGH concentration-time curves were fitted to a one-compartment model. The rhGH decorated by polyethylene glycol could prolong the action duration of rhGH in vivo, and reach the goal of long-action.