Abstract: Seven new compounds, 1,7-bis-(2-dialkylaminomethyl-4-substituted-phenoxy)-heptanes, have been prepared from 1,7-dibromoheptane and 2-dialkylaminomethyl-4-substituted-phenols in the presence of potassium hydroxide. By using this method, 1,7-bis-(pnitrophenoxy)-heptane was obtained instead of the expected 1,7-bis-(2-dialkylaminomethyl-4-nitrophenoxy) heptane. The 1,7-bis (2-diethylaminomethyl-4-aminophenoxy)-heptane was formed by hydrolysis of the corresponding acetyl derivative. The bis-(dialkylamino)-methanes were adopted as Mannish reagents to react with 4-substitued-phenols. The yield of 2-diethylaminomethyl-4-nitrophenol is 73-75%. The above new compounds are to be tested for the activity against Schistosomiasis Japonica in experimentally infected animals. The results will be published elsewhere.