玄参的脂溶性化学成分

李医明; 蒋山好; 高文运; 朱大元

玄参的脂溶性化学成分

LIPOSOLUBLE CONSTITUENTS FROM THE ROOTS OF SCROPHULARIA NINGPOENSIS

LIPOSOLUBLE CONSTITUENTS FROM THE ROOTS OF SCROPHULARIA NINGPOENSIS,

摘要

摘要: 目的：研究中药玄参(Scrophularia　ningpoensis　Hemsl.)脂溶性部位的化学成分。方法：利用溶剂提取和硅胶等色谱方法对玄参乙醚可溶部位进行分离纯化，通过化学和光谱方法鉴定结构。结果：共分得10个化合物，分别鉴定为3-O-乙酰基-2-O-阿魏酰基-α-L-鼠李糖(I),3-O-乙酰基-2-O-对羟基肉桂酰基-α-L-鼠李糖(II),肉桂酸(III),4-羟基-3-甲氧基苯甲酸(IV),对甲氧基肉桂酸(V),4-羟基-3-甲氧基肉桂酸(VI),5-羟甲基糠醛(VII),熊果酸(VIII),β-谷甾醇(IX)，β-谷甾醇葡糖苷(X)。结论：化合物I,II为新化合物。化合物IV,V,VII,VIII为首次从该植物中分得。玄参脂溶性部位含有较多的酚性化合物。

Abstract: AIM: To investigate the liposoluble constituents of the roots of Scrophularia ninpoensis Hemsl.METHODS: The constituens were obtained by solvent extraction and chromatography on silica gel etc.. Their structures were elucidated by chemical and spectroscopic methods (IR, EIMS, ¹HNMR, ¹³CNMR, ¹H-¹H COSY, HMQC, HMBC). RESULTS: Ten compounds were isolated. Among them, compound I and II are new and identified as 3-O-acetyl-2-O-(3-methoxy-4-hydroxycinnamoyl)-α-L-rhamnose and 3-O-acetyl-2-O-(p-hydroxycinnamoyl)-α-L-rhamnose, respectively. The others were identified as known compounds: cinnamic acid (III), 4-hydroxy-3-methoxybenzoic acid (IV), p-methoxycinnamic acid (V), 4-hydroxy-3-methoxycinnamic acid (VI), 5-hydroxymethyl furfural (VII), ursolic acid (VIII), β-sitosterol(IX), β-sitosteryl glucoside (X). CONCLUSION: Compounds IV,V,VII and VIII were isolated from this plant for the first time. Most obtained constituens in ether soluble part of S. ningpoensis were phenolic derivatives.

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