林木兰, 刘玉凤, 吕永裕, 张惠琴, 郑维民. 抗心律失常药物的研究——2-(烷胺基)甲基-和2,6-双(烷胺基)甲基-4-(取代胺基)苯酚类化合物的合成J. 药学学报, 1981, 16(10): 757-761.
引用本文: 林木兰, 刘玉凤, 吕永裕, 张惠琴, 郑维民. 抗心律失常药物的研究——2-(烷胺基)甲基-和2,6-双(烷胺基)甲基-4-(取代胺基)苯酚类化合物的合成J. 药学学报, 1981, 16(10): 757-761.
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Lin Mulan, Liu Yufeng, Lu Yongyu, Zhang Huiqin , Zheng Weimin, . STUDIES ON ANTIARRHYTHMICS——SYNTHESIS OF 2-(ALKYLAMINO) METHYL-AND2,6-BIS-(ALKYLAMINO) METHYL-4-SUBSTITUTED AMINO PHENOLSJ. Acta Pharmaceutica Sinica, 1981, 16(10): 757-761.
Citation: Lin Mulan, Liu Yufeng, Lu Yongyu, Zhang Huiqin , Zheng Weimin, . STUDIES ON ANTIARRHYTHMICS——SYNTHESIS OF 2-(ALKYLAMINO) METHYL-AND2,6-BIS-(ALKYLAMINO) METHYL-4-SUBSTITUTED AMINO PHENOLSJ. Acta Pharmaceutica Sinica, 1981, 16(10): 757-761.
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抗心律失常药物的研究——2-(烷胺基)甲基-和2,6-双(烷胺基)甲基-4-(取代胺基)苯酚类化合物的合成

STUDIES ON ANTIARRHYTHMICS——SYNTHESIS OF 2-(ALKYLAMINO) METHYL-AND2,6-BIS-(ALKYLAMINO) METHYL-4-SUBSTITUTED AMINO PHENOLS

    摘要
  • 摘要: 已知某些带2-(烷胺基)甲基-4-氨基苯酚或2,6-双(烷胺基)甲基-4-氨基苯酚基团的抗疟药具有抗心律失常作用。为了寻找抗心律失常新药,我们合成了一系列取代的4-氨基苯酚类化合物,药理筛选结果表明其中约半数有对抗乌头硷引起的大鼠心律失常的活性。

     

    Abstract: Based on the fact that certain antimalarials containing 2-(alkylamino) methyl-4-aminophenol group or 2,6-bis (alkylamino) methyl-4-aminophenol group possess antiarrhythmic properties, a series of title compounds were synthesized. Preliminary pharmacological tests showed that some of these compounds were effective against aconitine-induced experimental arrhythmia in rats.

     

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