BLyS和APRIL调节T细胞反应在类风湿关节炎中的研究进展

Progress in the study of BLyS and APRIL on regulating T cell responses in rheumatoid arthritis

摘要:
肿瘤坏死因子配体超家族成员B淋巴细胞刺激因子 (B lymphocyte stimulator, BLyS) 与其受体 (TACI、BCMA、BAFF-R) 结合, 调控B细胞的存活和活化。同时, BLyS也调节T细胞的功能, 促进T细胞的活化和存活, 在T细胞介导的自身免疫病中发挥重要作用。本文综述了BLyS及其同系物增殖诱导配体 (a proliferation-inducing ligand, APRIL)−受体在调节T细胞反应和在RA病理机制中的作用, 以及BLyS/APRIL靶向治疗RA药物的研究进展。

Abstract:
B lymphocyte stimulator (BLyS), a tumor neurosis factor ligand superfamily, is an important factor of B cell survival and activation. However, BLyS also regulates T cell activation and survival, playing key roles in T cell-mediated autoimmune disorders. In the paper, we introduced the mechanisms of BLyS and a proliferation-inducing ligand (APRIL) regulating T cell responses and their roles in rheumatoid arthritis (RA).