酸枣仁与五味子防治烧伤的实验观察
EFFECT OF SEMEN ZIZYPHI AND FRUCTUS SCHIZANDRAE ON EXPERIMENTAL BURN
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摘要: 作者观察到酸枣仁(5.0克/公斤)、五味子(1.0克/公斤)单用或合用(酸枣仁1.0—5.0克/公斤,五味子0.5—1.0克/公斤)均能提高烫伤小白鼠的存活率,延长存活时间;酸枣仁与五味子配伍还能推迟大白鼠烧伤休克的发生和延长存活时间,并能减轻小白鼠烧伤局部的水肿。此外,溴化钠与咖啡因的合剂(溴化钠0.5—1.0克/公斤,咖啡因0.002—0.025克/公斤)对小白鼠烫伤和大白鼠烧伤休克均有较良好的影响;吗啡0.025克/公斤对小白鼠烫伤水肿有显著的减轻作用。本实验中,冬眠合剂Ⅰ号(氯丙嗪0.01克/公斤,异丙嗪0.01克/公斤,嘜啶0.02克/公斤)及氯丙嗪(0.01克/公斤)对烧伤皆无防治效果。作者在本文中就酸枣仁与五味子防治烧伤的作用机制,进行了讨论。Abstract: The burns on mice and rats were produced by hot water and coagulated gasoline, respectively. The extracts of Semen Zizyphi and Fructus Schizandrae were found to cause an elevation in the survival rate and a prolongation in the survival time of mice. The combined use of Semen Zizyphi and Fructus Schizandrae delayed the development of shock, lengthened the survival time in rats and alleviated local oedema in mice. Sodium bromide (0.5—1.0g/kg) with caffeine (2—25 mg/kg) had a definite therapeutic effect on both mice and rats. Morphine (25 mg/kg) showed a remarkable alleviatire effect on the development of oedema.
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