何首乌乙酸乙酯不溶部分化学成分的研究

CHEMICAL STUDIES ON THE ETHYL ACETATE INS0LUBLE FRAC—TION OF THE ROOTS OF POLYGONUM MUTIFLOUM THUNB

摘要: 从四川何首乌(polygonu mnultiflorum Thunb)块根乙醇提取物的乙酸乙酯不溶部分分离得到五个单体,经理化常数测定,光谱(IR,UV,FAB-MS,¹HNMR,¹³CNMR,¹H-¹³CCOSY和NOE差谱)分析及衍生物制备,确定了两个化合物的结构为新化合物。化合物Ⅰ1,3-二羟基-6,7-二甲基酮-1-O-β-D-葡萄糖甙,命名为何首乌乙素,化合物Ⅱ为2,3,5,4′-四羟基-二苯乙烯-2,3-二-O-β-D葡萄糖甙,命名为何首乌丙素。其余三个结晶因量少有待进一步分离、鉴定。

Abstract: Two new compounds were isolated from the ethyl acetate insoluble fraction of the roots of Polygonum multiflorum Thunb.The structures of polygonimitin B and C have been established as1,3- dihydroxy-6,7-dimethylxanthone-l-O-β-D-glucoside(Ⅰ) and 2,3,5,4’- tetrahydroxystilbene-2,3-O-β-D glucoside(Ⅱ), respectively,by spectroscopic methods(UV,IR,FAB- MS,¹HNMR,¹³CNM R,¹H-¹³C COSY and NOE different spectrum).