Abstract: The paper described a delivery system prepared from granulation of a chitosan solution containing rotundine in a coagulating bath and examined the effects of the ratios of rotundine: chitosan, crosslinking agents and molecular weight of chitosan on the analgesic release rate. It was shown that the rotundine (56.7%) -chitosan (Mw :5.70×10⁵ degree of deacetylation: 72.4%)gelled granules in an artificial gastroenteric juice (pH 1.0 and 7.2 ) have T₅₀ of 40 and 180 min respectively, and the total release time sustained over 540 min.