红花黄色素A在小鼠体内的分布

Study on distribution of safflor yellow A in tissues of mice

摘要: 目的对红花黄色素A在小鼠体内的代谢、分布等药动学指标进行考察。方法建立生物样品中红花黄色素A的HPLC测定法,并测定了小鼠给药后的组织中药物浓度。结果小鼠尾静脉注射(31.8 mg·kg^-1)红花黄色素A后,药物在小鼠体内AUC的大小顺序为血、肾、肝、肺、心、脾,脑中未检测到。结论该药物在体内分布迅速且分布较广。

Abstract: AimTo study the distributive character of safflor yellow A in mice. MethodsA RP-HPLC method for the determination of safflor yellow A in tissues was established and applied to determine safflor yellow A in biological samples. ResultsAfter iv injection of Safflor yellow A in mice, the AUC of safflor yellow A was hightest in plasma, followed by kidney, liver, lung, heart, spleen. But it was not found in the brain. ConclusionThe distribution of safflor yellow A in the body is abroad and the speed of its process is swift.