张广明, 许德余, 计国桢, 吴秋业, 常志初. 叶绿素降解产物金属络合物的合成及其对60Co辐射小鼠的放射保护作用J. 药学学报, 1998, 33(10): 748-754.
引用本文: 张广明, 许德余, 计国桢, 吴秋业, 常志初. 叶绿素降解产物金属络合物的合成及其对60Co辐射小鼠的放射保护作用J. 药学学报, 1998, 33(10): 748-754.
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Zhang Guangming, Xu Deyu, Ji Guozhen, Wu Qiuye , Chang Zhichu, . STUDIES ON THE SYNTHESIS AND EXPERIMENTAL THERAPEUTIC EFFECTS OF METAL CHLORIN ON 60Co-IRRIDIATED MICEJ. Acta Pharmaceutica Sinica, 1998, 33(10): 748-754.
Citation: Zhang Guangming, Xu Deyu, Ji Guozhen, Wu Qiuye , Chang Zhichu, . STUDIES ON THE SYNTHESIS AND EXPERIMENTAL THERAPEUTIC EFFECTS OF METAL CHLORIN ON 60Co-IRRIDIATED MICEJ. Acta Pharmaceutica Sinica, 1998, 33(10): 748-754.
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叶绿素降解产物金属络合物的合成及其对60Co辐射小鼠的放射保护作用

STUDIES ON THE SYNTHESIS AND EXPERIMENTAL THERAPEUTIC EFFECTS OF METAL CHLORIN ON 60Co-IRRIDIATED MICE

    摘要
  • 摘要: 通过蚕沙叶绿素的降解反应,研究了焦脱镁叶绿酸a、二氢卟吩e6单甲酯及紫红素18等二氢卟吩衍生物的制备方法,首次设计合成了蚕沙叶绿素降解产物的钴、铜、锌金属络合物。在确认结构的基础上观察了它们对60Co辐射小鼠的放射治疗作用,结果发现二氢卟吩e6单甲酯铜络合物(7)能显著延长实验小鼠的存活时间,增加21d后小鼠存活数量。

     

    Abstract: Pheophorbide a and pyropheophorbide a were prepared by acid degradation of crude chlorophylls isolated from silkworm excrement. Pheophorbide a was further degradated to chlorin e6 monomethyl ester in alkaline methanol in absence of oxygen.Pure purpurin 18 was directly prepared from alkali degradation of silkworm excrement crude chlorophylls in presence of oxygen. Nine chlorin complexes of Co,Cu and Zn were synthesized for the first time.Preliminary pharmacological tests showed that chlorin e6 monomethyl ester copper complex(7) could increase survival and prolong the surviving time of 60Co-irridiated mice significantly.

     

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