当归中新的二聚苯酞衍生物

New dimeric phthalide derivative from Angelica sinensis

摘要: 目的深入研究中药当归Angelica sinensis的化学成分。方法用硅胶柱色谱法和光谱分析法分离和鉴定化学成分。结果除3个已知的苯酞类结构外，从当归中又分离到1个新的二聚苯酞衍生物和一对几何异构体，经光谱分析鉴定其结构分别为Z-3′,8′,3′a,7′a-四氢-6,3′,7,7′a–二聚藁本内酯-8′-酮(1)、Z,Z′-6,6′,7,3′a-二聚藁本内酯(2)和2的8位几何异构体(3)。结论化合物1为新的二聚苯酞类衍生物，3为首次从当归中鉴定的二聚苯酞类衍生物。

Abstract: AimTo study the chemical constituents of the roots of Angelica sinensis. Methods Silica gel column chromatography was used to separate the chemical constituents. Their structures were elucidated by chemical and spectral analysis (IR, MS, 1D and 2D NMR, etc.). ResultsBesides three known phthalide derivatives, one new dimeric phthalide derivative and a pair of epimer were isolated and their structures were identified as Z-3′,8′,3′a,7′a-tetrahydro-6,3′,7,7′a-diligustilide-8′-one (1), Z,Z′-6,6′,7,3′a-diligustilide (2) and the 8-epimer (3) of 2 on the basis of spectral data. Conclusion Compound 1 is a new dimeric phthalide derivative, and compound 3 was first reported from radix Angelica sinensis.