HPLC/ELSD指纹图谱和星座图聚类法在清开灵注射液质量评价中的应用

Application of HPLC/ELSD fingerprint and constellation graphical clustering method applied to evaluate the quality of Qingkailing injection

摘要: 目的对清开灵注射液的质量进行科学评价，为有效控制中药质量提供一种可靠方法。方法采用HPLC/ELSD指纹图谱技术结合星座图聚类法，测定不同厂家的18个批次清开灵注射液的指纹图谱，并评价产品质量。结果本法直观、准确地表达了产品的质量信息。结论本法是中药质量评价的一种直观、合理、有效的技术手段。

Abstract: AimTo evaluate the quality of Qingkailing injections effectively, and to develop a credible method for the quality control of traditional Chinese medicine. MethodsFingerprints of 18 Qingkailing injection samples from various manufacturers were obtained by HPLC/ELSD, and quality evaluation was performed by constellation graphical clustering method. ResultsHPLC/ELSD and constellation graphical clustering method properly revealed the quality information apparently and accurately. ConclusionIt was an apparent, credible and efficient method for quality evaluation of Chinese medicines.