天然前列腺素F2α的合成
SYNTHESIS OF THE NATURALLY OCCURRING PROSTAGLANDIN F2α
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Abstract: In a previous paper(1) we reported a stereocontrolled synthesis of recemic form of PGF2α. In this note we outline the synthesis of PGF2α following essentially the same approach but via a resolution of the intermediate dl-lactone (Ⅰ) and using the l-form (Ⅰa) for the subsequent steps resulting in the naturally occurring PGF2α. While from the d-lactone (Ⅰb)ent-13-dehydro-15-epi-PGF2α was obtained as the parallel end product.
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