2005-2008年抗HIV-1化学治疗新药的重要研究进展

Advances in novel anti-HIV-1 drugs and drug candidates: 2005 − 2008

摘要:
人类免疫缺陷病毒 (human immunodeficiency virus, HIV) 和获得性免疫缺陷综合征 (acquired immunodeficiency syndrome, AIDS) 仍然是全球关注的健康问题, 研究开发新型抗HIV化学药物具有重要意义, 上市新药的成功研发案例对此可能有借鉴之处。本文对2005～2008年间FDA批准上市的抗HIV-1化学药物及部分候选药物的发现过程和生物活性特点进行了综述。

Abstract:
HIV and AIDS remain as the crucial global health concern, therefore, research and development of novel anti-HIV-1 chemical therapeutics is still of paramount significance, which may be illuminated by cases of successful marketed drugs. Herein, we document the discovery and biological profile of new anti-HIV-1 drugs approved by FDA between 2005 and 2008 and some drug candidates are also discussed.