苦玄参中一个新葫芦苦素成分的分离与结构鉴定

Isolation and identification of a new cucurbitacin from Picria fel-terrae

摘要: 目的研究苦玄参中的化学成分。方法用硅胶和MCI柱色谱分离纯化，通过光谱(IR，UV，MS，¹HNMR，¹³CNMR，DEPT，HMQC，¹H-¹H COSY和HMBC)鉴定其化学结构。结果得到2个葫芦苦素类化合物，分别鉴定为11,24-二酮-5,21-二烯葫芦苦素-3α-O-β-D-吡喃木糖基-16α-O-α-L-吡喃鼠李糖苷(脱氢拜俄尼苷，1)和己降葫芦苦素F(2)。结论化合物1为新化合物，化合物2为首次从苦玄参中分离得到。

Abstract: AimTo study compounds isolated from Picria fel-terrae. MethodsThe chemical constituents were separated and purified by column chromatography on silica gel and MCI. Their structures were identified on the basis of spectral data (IR, UV, MS, 1D NMR and 2D NMR). ResultsA new cucurbitacin, along with a known one, were obtained from the 60% EtOH extract of the whole plant. ConclusionThe new compound was identified as 11,24-dioxo-5,21-diene-cucurbit-3α-O-β-D-xylopyranosyl-16α-O-α-L-rhamnopyranoside (dehydrobryogenin glycoside). The known one, hexanorcucurbitacin F, was obtained for the first time from Picria fel-terrae.