Abstract: On the basis of our previous work in which some aminomethylphenol derivatives were found to possess significant antiinflammarory activity, twenty eight derivatives of 4-heteroaryl-mono/di-aminomethylphenol were designed and synthesized in attempt to search for potent NSAID with less side effects. The title compounds were prepared by means of Mannich reaction.Twenty of the compounds were tested in rats for antiinflammatory activity. Most compounds showed antiinflammatory activity in varied degrees and some showed significant activity. Quantum chemical calculation of ten of the compounds were carried out by means of CNDO/2 method. The relationship between antiinflammatory activity and electronic structural feature of the compounds were discussed.