郝大程,肖培根,彭勇,刘明,霍利. 红豆杉药物资源的生物学和化学研究进展及趋势分析J. 药学学报, 2012,47(7): 827-835.
引用本文: 郝大程,肖培根,彭勇,刘明,霍利. 红豆杉药物资源的生物学和化学研究进展及趋势分析J. 药学学报, 2012,47(7): 827-835.
HAO Da-cheng, XIAO Pei-gen, PENG Yong, LIU Ming, HUO Li. Research progress and trend analysis of biology and chemistry of Taxus medicinal resourcesJ. 药学学报, 2012,47(7): 827-835.
Citation: HAO Da-cheng, XIAO Pei-gen, PENG Yong, LIU Ming, HUO Li. Research progress and trend analysis of biology and chemistry of Taxus medicinal resourcesJ. 药学学报, 2012,47(7): 827-835.

红豆杉药物资源的生物学和化学研究进展及趋势分析

Research progress and trend analysis of biology and chemistry of Taxus medicinal resources

  • 摘要:

    红豆杉是抗癌药紫杉醇及其半合成前体的重要来源, 近几十年受到了广泛关注。我国拥有多种特有的红豆杉物种, 研究者已经对其进行了多学科综合研究。本文结合作者近年研究, 综述了多种红豆杉药物资源的生物学和化学研究技术、现状及具体面临的问题, 运用信息计量方法考察红豆杉相关SCI文献的词频分布, 为红豆杉研究趋势的分析预测提供定量依据。本文结合近年系统生物学和组学技术的研究进展, 指出应尽快深入研究各种红豆杉及其内生真菌的基因组、表观基因组、转录组、蛋白质组、代谢组和生物信息学, 全面推动红豆杉药物资源的可持续开发利用。

     

    Abstract:

    Taxus is the source plant of anti-cancer drug paclitaxel and its biosynthetic precursor, analogs and derivatives, which has been studying for decades.  There are many endemic Taxus species in China, which have been studied in the field of multiple disciplines.  Based on the recent studies of the researchers, this review comments on the study of Taxus biology and chemistry.  The bibliometric method is used to quantify the global scientific production of Taxus-related research, and identify patterns and tendencies of Taxus-related articles.  Gaps are present in knowledge about the genomics, epigenomics, transcriptomics, proteomics, metabolomics and bioinformatics of Taxus and their endophytic fungi.  Systems biology and various omics technologies will play an increasingly important role in the coming decades.

     

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