中药秦皮的化学研究

CHMICAL STUDIES ON, THE CHINESE DRUG QIN PI, THE BARK OF FRAXINUS STYLOSA

摘要: 通过聚酰胺柱层析和制备型硅胶高压柱层析,从秦皮(Fraxinus stylosa Lingelsh)的乙醇提取物中分离到五种成分,根据光谱分析、物理化学常数测定及水解产物的制备,证实其中三种为香豆素郧七叶亭、七叶灵和梣皮甙;一种为酚甙(丁香甙);另外一种为新的天然产物,证明其结构是香豆素多糖甙、甙元为7,8-二羟基-6-甲氧基香豆素,8位羟基连有一分子葡萄糖和两分子鼠李糖,命名为宿柱白蜡甙(Stylosin)。香豆素的多糖甙在自然界中极少发现。从中国秦皮(包括中国药典规定的三个品种)中分离出檸皮甙和丁香甙,过去文献尚未报道。

Abstract: Four coumarins and a phenolic glycoside were isolated from the bark of Fraxinus stylosa Lingelsh: esculetin, es-culin, fraxin, syringin and anew coumaric glycoside—stylosin. On the basis of spectroscopic analyses (IR, UV, MS) and physico—chemical constants, the structure of stylosin was identified as 8-O-(rhamnosyl-rhamnosyl-glucosyl)-fraxetin.