中药组方原则&ldquo;君臣佐使&rdquo;的模糊数学量化描述

中药组方原则“君臣佐使”的模糊数学量化描述

摘要: 探讨中药“君臣佐使”的微观意义以及模糊数学量化描述方法; 根据“君臣佐使”的分子生物学表达和最大隶属度原则, 对应于证候模型各靶点和功能群提出“君臣佐使”模糊子集和隶属度函数的计算方法; 以四物汤为例, 根据四物汤各单药对辐射小鼠骨髓造血的调节作用试验, 依据最大隶属度原则, 得出地黄和当归属于“君臣药”模糊子集, 白芍属于“反佐”模糊子集, 川芎属于“使药”模糊子集; 讨论模糊数学是“君臣佐使”更为本质的数学表达。

Abstract: This study is to analyze microcosmic significance of Chinese medicine composing principle “principal, assistant, complement and mediating guide” and it’s fuzzy mathematic quantitative law. According to molecular biology and maximal membership principle, fuzzy subset and membership functions were proposed. Using in vivo experiment on the effects of SiWu Decoction and its ingredients on mice with radiation-induced blood deficiency, it is concluded that DiHuang and DangGui belonged to the principal and assistant subset, BaiShao belonged to the contrary complement subset, ChuanXiong belonged to the mediating guide subset by maximal membership principle. It is discussed that traditional Chinese medicine will be consummate medical science when its theory can be described by mathematic language.