四倍体板蓝根中的一个新生物碱四倍体板蓝根中的一个新生物碱

A new alkaloids isolated from tetraploidy Banlangen

摘要: 目的研究四倍体菘蓝Isatis indigotica Fort.根的化学成分。方法用大孔树脂和硅胶柱色谱对正丁醇萃取部分的化学成分进行分离纯化,应用理化常数测定和光谱(IR,MS,¹HNMR,¹³CNMR,2D-NMR)分析技术鉴定结构。结果从正丁醇萃取部位分离得到1个生物碱和2个木脂素类化合物,分别鉴定为：(E)-2-［(3′-吲哚)腈基亚甲基］-3-吲哚酮(I),2-(4-羟基-3-甲氧基-苯基)-4-［(4-羟基-3-甲氧基-苯基)-甲基］-3-羟甲基-四氢呋喃(II),2-甲氧基-4-四氢-4-［(4-羟基-3-甲氧基-苯基)-甲基］-3-羟甲基-2-呋喃基苯基-1-O-β-D-葡糖苷(III)。结论I为新化合物,II,III为首次从该种植物中分离得到。

Abstract: AimTo investigate the chemical constituents of tetraploidy Banlangen (Isatis indigotica Fort.). MethodsCompounds were separated by chromatography on silica gel. Their structures were determined by spectral analysis and chemical evidence. ResultsThree compounds were isolated. Their structures were identified as (E)-2-［(3′-indole) cyanomethylene］-3-indolinone (I), 2-(4-hydroxy-3-methoxy-phenyl)-4-［(4-hydroxy-3-methoxy-phenyl)-methyl］-3-hydroxymethyl-tetrahydro-furan (II) and 2-methoxy-4-［tetrahydro-4-［(4-hydroxy-3-methoxy-phenyl)-methyl］-3-hydroxymethyl-2-furanyl］phenyl-1-O-β-D-glucopyranoside (III). ConclusionCompound I is a new compound.