Abstract: A series of β-substituted para-ch-lorocinnamamide compounds were designed for the study of the relationship between chemical structure and anticonvulsant activity. Three compounds (β-C₂H₅, β-C₃H₇,β-NH₂ substituted) were found to show higher activity.The relationships between chemical structure and anticonvulsant activity were discussed.1. Electron-repelling substituting groups are favourable to the anticonvulsant activity.2. The existence of resonance in the molecule seems essential for the anticonvulsant activity.