孙梅贞, 朱佩萼, 唐诚, 陈爱芬, 沈彬源. N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果J. 药学学报, 1990, 25(7): 505-508.
引用本文: 孙梅贞, 朱佩萼, 唐诚, 陈爱芬, 沈彬源. N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果J. 药学学报, 1990, 25(7): 505-508.
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MZ Sun, PE Zhu, C Tang, AF Chen , BY Shen, . SYNTHESIS OF N,N '-ALKYLENE-BIS-(SUBSTITUTEDPHENOL)GLYCINE FOR REMOVAL OF RADIO-ACTINIDES IN RATSJ. Acta Pharmaceutica Sinica, 1990, 25(7): 505-508.
Citation: MZ Sun, PE Zhu, C Tang, AF Chen , BY Shen, . SYNTHESIS OF N,N '-ALKYLENE-BIS-(SUBSTITUTEDPHENOL)GLYCINE FOR REMOVAL OF RADIO-ACTINIDES IN RATSJ. Acta Pharmaceutica Sinica, 1990, 25(7): 505-508.
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N,N′-亚烷基双(取代苯酚)氨基乙酸的合成及对放射性核素钍-234的促排效果

SYNTHESIS OF N,N '-ALKYLENE-BIS-(SUBSTITUTEDPHENOL)GLYCINE FOR REMOVAL OF RADIO-ACTINIDES IN RATS

    摘要
  • 摘要: 本文报道合成的16个N,N′-亚烷基双(取代苯酚)氨基乙酸除化合物3,4外对放射性钍-234的加速排出均有较好的效果。其中有二个化合物促排效果达到70%以上,根据动物实验结果初步探讨了构效关系。

     

    Abstract: The synthesis of 16 compounds of N, N'-alkylene-bis (substituted phenol) glycine is reported. They showed good effects on the removal of redinuclide thorium-234 from rats, except compound 3 and compound 4. Two of them can remove more than 70% of injected thorium. The relationship between structure and effects of these compounds was discussed.

     

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