Abstract: Four new triterpenoids have been isolated from the petroleum ether extract of Cynanchum hancockianum (Maxim)Al. Iljinski (Asclepiadaceae). On the basis of spectral data (¹HNMR, ¹³CNMR, ¹H-¹H COSY, ¹H-¹³C COSY, longrange ¹H-¹³C COSY, MS, X-Ray analysis) and chemical connections, they were identified as hancockinol (Ⅰa), hancolupenol (Ⅱa), hancolupenone (Ⅱc), and hancolupenol octacosanate (Ⅱd). They are of new skeletons with B/C cis, C/D trans, D/E cis junctures for Ⅰa and with A/B trans, C/D trans, D/E cis junctures for Ⅱa, Ⅱc and Ⅱd.