川东獐牙菜一个新酮的研究

Daviditin B from Swertia davidi Franch.

摘要: 目的研究川东獐牙菜(Swertia davidi Franch.)抗氧化活性成分。方法用柱色谱技术分离化学成分,利用UV,IR,NMR,MS等方法确证化合物结构,采用DPPH方法研究了7个酮类化合物的抗氧化活性。结果得到3个化合物,分别鉴定为:2,5-二甲氧基-1,4-二羧基苯(VIII);1,5,8-三羟基-3,4-二甲氧基酮(IX)和1,8-二羟基-3-(3′-羟基-丁氧基)酮(X)。结论X为新化合物,具有较强的抗氧化活性;VIII和IX为首次从该植物中分离得到。

Abstract: AimTo study the active constituents of Swertia davidi Franch. MethodsChemical components were isolated by column chromatography and their structures were established mainly by spectroscopic means (UV, IR, NMR, 2D-NMR, MS). ResultsThree substances were identified as 2,5-dimethoxyl-1,4-dicarboxyl benzene (VIII), 1,5,8-trihydroxyl-3,4-dimethoxyl xanthone (IX) and 1,8-dihydroxyl-3-(3′-hydroxyl-butoxy) xanthone (X). ConclusionCompounds VIII and IX were isolated from Swertia davidi Franch. for the first time, whereas compound X is a new xanthone, named daviditin B with antioxygenated activity in vitro.