赵晶, 张致平, 陈鸿珊, 陈湘红. 金丝桃素与乙基金丝桃素的全合成及对人免疫缺陷病毒逆转录酶的抑制活性J. 药学学报, 1998, 33(1): 67-71.
引用本文: 赵晶, 张致平, 陈鸿珊, 陈湘红. 金丝桃素与乙基金丝桃素的全合成及对人免疫缺陷病毒逆转录酶的抑制活性J. 药学学报, 1998, 33(1): 67-71.
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Zhao Jing, Zhang Zhiping, Chen Hongshan , Chen Xianghong, . STUDIES ON SYNTHESIS AND ANTI-HIV RT ACTIVITY OF HYPERICIN AND ETHYLHYPERICINJ. Acta Pharmaceutica Sinica, 1998, 33(1): 67-71.
Citation: Zhao Jing, Zhang Zhiping, Chen Hongshan , Chen Xianghong, . STUDIES ON SYNTHESIS AND ANTI-HIV RT ACTIVITY OF HYPERICIN AND ETHYLHYPERICINJ. Acta Pharmaceutica Sinica, 1998, 33(1): 67-71.
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金丝桃素与乙基金丝桃素的全合成及对人免疫缺陷病毒逆转录酶的抑制活性

STUDIES ON SYNTHESIS AND ANTI-HIV RT ACTIVITY OF HYPERICIN AND ETHYLHYPERICIN

    摘要
  • Abstract: Condensed polycyclic anthraquinone hypericin and its analogues showed activity against several retroviruses, including human immunodeficiency virus (HIV). Another condensed polycyclic anthraquinone ethylhypericin was synthesized from butanone in order to compare its biological activity with hypericin. Biological activity showed that ethylhypericin was slightly more effective than hypericin in HIV-RT inhibitory test.

     

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