芒柄花素磺化物的合成、溶解性能及降脂保肝活性

Synthesis, solubility, lipids-lowering and liver-protection activities of sulfonated formononetin

摘要:
以芒柄花素为先导化合物, 利用磺化反应合成了具有降脂保肝活性的水溶性新化合物芒柄花素-3′-磺酸钠，通过IR、NMR、元素分析对其结构进行了表征。采用紫外分光光度法测定了芒柄花素-3′-磺酸钠的溶解度和正辛醇/水分配系数；采用高脂饮食诱导大鼠高脂模型，进行了降脂保肝的药理活性试验。实验结果表明芒柄花素-3′-磺酸钠不仅具有良好的水溶性，而且具有好的降脂保肝活性。

Abstract:
A water-soluble compound, sodium formononetin-3′-sulfonate with good lipid-lowering and liver-protection activities was synthesized. It was synthesized by sulfonation reaction, and its structure was characterized by IR, NMR and elemental analyses. The solubility of sodium formononetin-3′-sulfonate in water and n-octanol/water partition coefficient were determined by UV spectrophotometry. The lipid-lowering and liver-protection activities of sodium formononetin-3′-sulfonate were tested by using rat’s high fat model induce by feeding with high fat food. The results showed that sodium formononetin-3′-sulfonate not only had favorable water solubility but also had good lipid-lowering and liver-protection activities.