孙国祥, 侯志飞, 毕雨萌, 毕开顺, 孙毓庆. 中药色谱指纹图谱潜信息特征判据研究J. 药学学报, 2006, 41(9): 857-862.
引用本文: 孙国祥, 侯志飞, 毕雨萌, 毕开顺, 孙毓庆. 中药色谱指纹图谱潜信息特征判据研究J. 药学学报, 2006, 41(9): 857-862.
shu
SUN Guo-xiang, HOU Zhi-fei, BI YU-meng, BI Kai-shun, SUN Yu-qing. The digital criterion of the potential information characteristics of the traditional Chinese medicine chromatographic fingerprintsJ. Acta Pharmaceutica Sinica, 2006, 41(9): 857-862.
Citation: SUN Guo-xiang, HOU Zhi-fei, BI YU-meng, BI Kai-shun, SUN Yu-qing. The digital criterion of the potential information characteristics of the traditional Chinese medicine chromatographic fingerprintsJ. Acta Pharmaceutica Sinica, 2006, 41(9): 857-862.
shu

中药色谱指纹图谱潜信息特征判据研究

The digital criterion of the potential information characteristics of the traditional Chinese medicine chromatographic fingerprints

    摘要
  • 摘要: 目的对中药色谱指纹图谱潜信息特征进行判据研究，用F和I等37个指标揭示色谱指纹图谱的潜信息特征。方法用银杏叶提取物(GBE)、银杏达莫注射液(GLEDI)和苦碟子(ISH)与苦碟子注射液(ISHI)的HPLC指纹图谱进行比较研究。结果从积分信号强度、信号均化程度、分离度、指纹信息量等多方面综合评价出GBE指纹图谱好于GLEDI，ISH指纹图谱好于ISHI，GBE与ISH指纹图谱基本相当。结论F和I等37个指标可客观、真实、全面地揭示中药指纹图谱的潜信息特征。

     

    Abstract: AimTo exploit the characteristic digital criterion for the potential information characteristics of traditional Chinese medicine chromatographic fingerprints, the 37 parameters such as F andI were firstly proposed to disclose the potential information characteristics of traditional Chinese medicine fingerprints. MethodsThe HPLC fingerprints of the Ginkgo biloba extract (GBE), Ginkgo leaf extract and diphyridamole injection (GLEDI), Ixeris sonchifolia Hance (ISH) and Ixeris sonchifolia Hance injection (ISHI) were compared each other. ResultsAs far as the peak signal intensity, the uniform of peak signal, resolution and the fingerprint information were concerned. The GBE fingerprint was better than the GLEDI’s, and the ISH fingerprint was also better than the ISHI’s, then GBE fingerprint was close to the ISHI’s. ConclusionThe 37 parameters such as F andI can be used to objectively, authentically and thoroughly display the potential information characteristics of the traditional Chinese medicine chromatographic fingerprints.

     

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