黄丝郁金中的生物碱和倍半萜类成分

Alkaloid and sesquiterpenes from the root tuber of Curcuma longa

摘要: 姜科植物姜黄(Curcuma longa)的块根称为黄丝郁金，是常用中药郁金的来源之一。为了研究黄丝郁金的利胆活性成分，采用柱色谱法对姜黄干燥块根的化学成分进行了研究。本文主要报道从中分离得到的1个喹啉类生物碱2-(2′-methyl-1′-propenyl)-4,6-dimethyl-7-hydroxyquinoline (1)，7个没药烷型倍半萜2,5-dihydroxybisabola-3,10-diene (2), 4,5-dihydroxybisabola-2,10-diene (3), turmeronol A (4), bisacurone (5), bisacurone A (6), bisacurone B (7)和bisacurone C (8)，以及dehydrozingerone (9)和zingerone (10)的分离和鉴定。化合物1为一个新的生物碱类化合物，化合物6～8为首次从姜黄中分得，化合物9～10为首次从姜黄属植物中分离得到。

Abstract: One new quinoline alkaloid and seven known bisabolane sesquiterpenes: 2-(2′-methyl-1′-propenyl)-4,6-dimethyl-7-hydroxyquinoline (1), 2,5-dihydroxybisabola-3,10-diene (2), 4,5-dihydroxybisabola-2,10-diene (3), turmeronol A (4), bisacurone (5), bisacurone A (6), bisacurone B (7), bisacurone C (8), as well as dehydrozingerone (9) and zingerone (10) were isolated from the root tuber of Curcuma longa. Their structures were identified by spectral evidence. Compound 1 is a new compound, compounds 6-8 were isolated from this plant for the first time and compounds 9-10 from Curcuma for the first time.