毛曼君, 陈耀祖, 田瑄. 杂环化合物取代的5-氟尿嘧啶衍生物的合成及抗肿瘤活性J. 药学学报, 1998, 33(5): 389-391.
引用本文: 毛曼君, 陈耀祖, 田瑄. 杂环化合物取代的5-氟尿嘧啶衍生物的合成及抗肿瘤活性J. 药学学报, 1998, 33(5): 389-391.
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Mao Manjun, Chen Yaozu , Tian Xuan, . SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW HETEROCYCLIC 5-FLUOROURACIL DERIVATIVESJ. Acta Pharmaceutica Sinica, 1998, 33(5): 389-391.
Citation: Mao Manjun, Chen Yaozu , Tian Xuan, . SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW HETEROCYCLIC 5-FLUOROURACIL DERIVATIVESJ. Acta Pharmaceutica Sinica, 1998, 33(5): 389-391.
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杂环化合物取代的5-氟尿嘧啶衍生物的合成及抗肿瘤活性

SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW HETEROCYCLIC 5-FLUOROURACIL DERIVATIVES

    摘要
  • Abstract: Two new compounds I and II of 5-FU derivatives have been systhesized. The structures of the new compounds were confirmed by 1HNMR, MS, IR, UV and elemental analysis. The antitumor activities of compound I was tested against KB, HCT-8 and A2780. The preliminary results showed that the activity of compound I was stronger than that of HCFU and 5-FU.

     

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