王斌, 张爱霞, 邹颖, 王娟, 肖继皋. TMB-8抑制5-HT和KCl引起大鼠脑血流量减少J. 药学学报, 2003, 38(5): 342-345.
引用本文: 王斌, 张爱霞, 邹颖, 王娟, 肖继皋. TMB-8抑制5-HT和KCl引起大鼠脑血流量减少J. 药学学报, 2003, 38(5): 342-345.
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WANG Bin, ZHANG Ai-xia, ZOU Ying, WANG Juan, XIAO Ji-gao. 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate inhibited the reduction of cerebral blood flow evoked by 5-HT and KCl in ratsJ. Acta Pharmaceutica Sinica, 2003, 38(5): 342-345.
Citation: WANG Bin, ZHANG Ai-xia, ZOU Ying, WANG Juan, XIAO Ji-gao. 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate inhibited the reduction of cerebral blood flow evoked by 5-HT and KCl in ratsJ. Acta Pharmaceutica Sinica, 2003, 38(5): 342-345.
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TMB-8抑制5-HT和KCl引起大鼠脑血流量减少

8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate inhibited the reduction of cerebral blood flow evoked by 5-HT and KCl in rats

    摘要
  • 摘要: 目的研究TMB-8对5-HT和KCl引起的大鼠脑血流量(CBF)减少的作用。方法用激光多普勒血流仪测量大鼠CBF,在人工脑脊液灌流液中加入TMB-8和工具药进行干预。结果12.5, 25和50 μmol·L-1 TMB-8对大鼠CBF无明显影响,TMB-8可抑制5-HT引起的大鼠CBF减少。在1 μmol·L-1 5-HT引起大鼠CBF持续下降的状态下,TMB-8可浓度依赖的增加大鼠CBF。TMB-8也可抑制KCl引起的大鼠CBF减少。在20 mmol·L-1 KCl引起大鼠CBF持续下降的状态下,TMB-8可浓度依赖的增加大鼠CBF。结论TMB-8可抑制5-HT和KCl引起的大鼠CBF减少,也可浓度依赖的增加被5-HT和KCl所减少的大鼠CBF,改善大鼠缺血区脑血供。

     

    Abstract: AimTo investigate the impact of 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate(TMB-8) on the change of cerebral blood flow(CBF) induced by 5-HT or KCl in rats.MethodsThe CBF in rats was measured by a Laser-Doppler flowmeter. The cranial window field was superfused with artificial cerebral spinal fluid containing TMB-8, 5-HT or KCl. Results12.5, 25 and 50 μmol·L-1 TMB-8 showed no significant effect on rest CBF in rats. 12.5, 25 and 50 μmol·L-1 TMB-8 apparently inhibited the decline of CBF evoked by 1 or 2 μmol·L-1 5-HT. When persistent reduction of CBF were evoked by 1 μmol·L-1 5-HT, TMB-8 markedly increased the CBF in a concentration-dependent manner. The reduction of CBF induced by 20 or 40 mmol·L-1 KCl was also suppressed by 12.5, 25 and 50 μmol·L-1 TMB-8. While persistent reduction of CBF was evoked by 20 mmol·L-1 KCl. TMB-8 markedly increased the CBF in a concentration-dependent manner.ConclusionThese results indicate that TMB-8 is effective in preventing and treating the reduction of CBF induced by 5-HT or KCl, and improved the supply of blood in rat brain during ischemia.

     

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