鞠建华, 林耕, 杨峻山, 逯海燕, 马柄娜, 聂淑芹, 张侠. 铁破锣皂苷O和P的结构及其药理活性J. 药学学报, 2002, 37(10): 788-792.
引用本文: 鞠建华, 林耕, 杨峻山, 逯海燕, 马柄娜, 聂淑芹, 张侠. 铁破锣皂苷O和P的结构及其药理活性J. 药学学报, 2002, 37(10): 788-792.
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JU Jian-hua, LIN Geng, YANG Jun-shan, LU Hai-yan, MA Bing-na, NIE Shu-qin, ZHANG Xia. STRUCTURES AND PHARMACOLOGICAL ACTIVITIES OF BEESIOSIDES O AND PJ. Acta Pharmaceutica Sinica, 2002, 37(10): 788-792.
Citation: JU Jian-hua, LIN Geng, YANG Jun-shan, LU Hai-yan, MA Bing-na, NIE Shu-qin, ZHANG Xia. STRUCTURES AND PHARMACOLOGICAL ACTIVITIES OF BEESIOSIDES O AND PJ. Acta Pharmaceutica Sinica, 2002, 37(10): 788-792.
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铁破锣皂苷O和P的结构及其药理活性

STRUCTURES AND PHARMACOLOGICAL ACTIVITIES OF BEESIOSIDES O AND P

    摘要
  • 摘要: 目的研究我国特有药用植物铁破锣［Bessia calthaefolia (Maxim.) Ulhr.］根茎的化学成分。方法利用各种色谱技术进行分离,根据化合物的光谱数据(IR,MS,1HNMR,13CNMR,2DNMR)和化学方法鉴定其结构,并对所得单体成分进行药理活性筛选。结果从甘肃产铁破锣根茎的氯仿萃取物中分离得到2个化合物,分别鉴定为:(20S,24S)-15α-acetoxy-16β,24;20,24-diepoxy-9,19-cyclolanostane-3β,25-diol-3-O-β-D-xylopyranoside (I)和(20S,24R)-15α-acetoxy-9,19-cyclolanostane-3β,16β,20,24,25-pentaol-3-O-β-D-xylopyranoside (II),分别命名为铁破锣皂苷O(beesioside O)和铁破锣皂苷P(beesioside P)。结论I和II为新化合物,I有免疫抑制、抑制血管生成和抑制成骨细胞增殖活性。

     

    Abstract: AIMTo investigate the chemical constituents of the rhizomes of Beesia calthaefolia native to China in order to obtain a more comprehensive understanding of its effective components. METHODSCompounds were isolated by column chromatography with silica gel. Their structures were elucidated by spectral analysis and chemical evidence. Compounds identified were subjected to pharmacological evaluation. RESULTSTwo novel compounds were isolated and identified as (20S,24S)-15α-acetoxy-16β,24;20,24-diepoxy-9,19-cyclolanostane-3β,25-diol-3-O-β-D-xylopyranoside (I) and (20S,24R)-15α-acetoxy-9,19-cyclolanostane-3β,16β,20,24,25-pentaol-3-O-β-D-xylopyranoside (II), named beesioside O and beesioside P. CONCLUSIONCompounds I and II are new compounds. Compounds I exhibited immunosuppressive activity and could inhibit angiogenesis as well as inhibit the proliferation of osteoblast. Compound II displayed remarkable inhibition activity against calcium channel receptor.

     

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